What Is O-desmethyltramadol? O-desmethyltramadol, also known as O-DMST, Desmetramadol, and M1, is an opioid analgesic belonging to a group of compounds known as Cyclohexanol. This...More
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What Is O-desmethyltramadol?
O-desmethyltramadol, also known as O-DMST, Desmetramadol, and M1, is an opioid analgesic belonging to a group of compounds known as Cyclohexanol. This class of compounds is characterized by having a cyclohexane bound to a phenol group.
Interest in O-desmethyltramadol increased significantly once it was shown to be an active metabolite of Tramadol, a commonly prescribed pain medication. Tramadol is demethylated by the CYP2D6 liver enzyme much the same way codeine is. Because of this, O-desmethyltramadol is said to cause similar effects to codeine when ingested. It is also worth noting that O-desmethyltramadol is significantly stronger than its parent molecule Tramadol.
Chemical Properties Of O-desmethyltramadol
Chemical Formula: C15H23NO2
Full Name: -[2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]phenol
Molecular Weight: 249.354g/mol
Although there has only been limited study on the effects of O-desmethyltramadol in humans, it shares many chemical properties with Tramadol and Codeine, two substances which have been studied to a much greater degree of depth.
Because of this, it can be reasonably assumed that O-desmethyltramadol works as a serotonin and noradrenaline reuptake inhibitor and acts upon the u-opioid receptors. Unlike Tramadol, O-desmethyltramadol has a comparatively high affinity for the k-opioid receptors, which are responsible for feelings of sedation, dissociation, and delirium.
Due to the minimal amount of human study conducted, exact dosage rates are not available. However, anecdotal evidence suggests that a threshold dose is somewhere around 15mg, with 30 - 50 mg being a more common dosage.
As with other opioids, onset usually begins in as little as 30 minutes, with peak effects occurring between 2 and 5 hours after ingestions..
Side Effects Of O-desmethyltramadol
O-desmethyltramadol can be safely assumed to have psychological and physiological effects similar to that of other, highly similar, opiates.
Pain Relief: Opioids are one of the oldest known pain relief medications, with evidence for opium use dating back as far as the neolithic age. Currently, many of the most popular and effective pain relief medications fall into this class of substances.
Euphoria: Opioids have high abuse potential because of their ability to induce feelings of euphoria in those who ingest them. Because of the relatively high strength of O-desmethyltramadol, this substance has high abuse potential.
Itchiness: Itchiness is a commonly reported sensation amongst long term opioid users. This occurs because many opiates cause an immune response in the body that results in the release of histamines, a compound that is responsible for the narrowing of blood vessels and is a cause of itching.
Sedation: Opioids depress the central nervous system, which, depending upon dosage, can produce a strong sense of sedation.
Constipation: The Gastrointestinal (GI) tract contains several neuron clusters that control muscles in the intestines that are responsible for pushing stool towards the rectum. When one ingests opioids, these muscles relax, slow down, and even sometimes stop working altogether. When this occurs, the user is left with a strong sense of constipation.
NOTE: O-desmethyltramadol has not been approved for human consumption and is for research purposes only.
Where To Buy O-desmethyltramadol?
At Chemical Planet, an N1 trusted source, we offer high quality, laboratory-grade O-desmethyltramadol. Chemical Planet is the premier option for those looking to buy research chemicals. Please note, you must be at least 18 years of age or older to buy O-desmethyltramadol from Chemical Planet. All research chemicals sold are for use in laboratory-based research and experimentation and not for human consumption.