Oxiracetam

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What Is Oxiracetam? Oxiracetam is a potent Nootropic of the Racetam class, being one of the first synthesized derivatives of Piracetam. Since its inception in the 1970s, this sma...More

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What Is Oxiracetam?

Oxiracetam is a potent Nootropic of the Racetam class, being one of the first synthesized derivatives of Piracetam.

Since its inception in the 1970s, this smart drug has been shown to enhance cognitive function and also acts as a mild stimulant [1], promoting wakefulness, focus, and clear-mindedness. Many users report effects similar to those of Piracetam, but more potent and pronounced.

Many users report that using an oxiracetam choline combination produces better results than taking oxiracetam by itself.

Oxiracetam Chemical Properties

Chemical Formula: C6H10N2O3

Molar Mass: 158.155 g·mol−

Although the exact mechanism of action is not fully understood, Oxiracetam functions the way all Racetams do, by stimulating the production of specific neuron receptors in the brain as well as associated neurotransmitters, with acetylcholine being the most prominent neurotransmitter involved in this process.

Oxiracetam is structurally very similar to its parent's compound Piracetam, differing only by an additional hydroxyl group at the R4 position. This slight difference in its chemical properties makes it more potent than Piracetam but may lower its bioavailability to 56% - 82% [2]

There is no exact oxiracetam dosage, as individuals vary widely in how much of the compound they require to experience its cognitive enhancing and stimulatory effects. This being said, the standard dose is typically between 500mg - 2400mg daily, broken up into three doses evenly spread apart.

Oxiracetam Dosage

Low: 500 - 1200 mg

Common: 1200 - 1800mg

High: 1800 - 2400mg

Oxiracetam is known to modulate Glutamatergic and Cholinergic systems to increase the production of the neurotransmitters acetylcholine and glutamate. These neurotransmitters play an important role in the formation of both long term and short term memories and are also crucial for proper cognitive functions.

Benefits Of Oxiracetam

Increases Neuronal Communication: Because of the modulation of certain neurotransmitters, Oxiracetam is observed to increase neuronal communication. This can be most acutely observed in the hippocampus, the part of the brain most closely associated with memory [3].

Enhances Cognitive Function: There is a reason that Racetams are referred to as smart drugs - they appear to enhance cognitive functions including memory formation and recall, spatial intelligence, and verbal fluidity [4].

Improves Memory: Perhaps it's the most well-studied benefit, Oxiracetam has been observed to increase cognition in those who are experiencing age-related cognitive decline [5]. Although little research has been conducted on its effects on individuals with standard cognitive function, numerous anecdotal reports indicate that it does help with memory formation, retention, and recall in healthy individuals.

Improves Focus And Concentration: One of the more unique effects of Oxiracetam is its stimulant-like properties. Just like stimulants used in the treatment of ADHD, Oxiracetam has been shown to be effective at improving focus and concentration [6]. Many users have compared the stimulant-like properties of Oxiracetam to those of caffeine.

Neuroprotective Qualities: Oxiracetams parents molecule, Piracetam, has long been investigated as a treatment to slow the progression of cognitive decline resulting from neurological disorders. Because of this, it should come as no surprise that Oxiracetam also exhibits neuroprotective qualities [7] [8]. Of all oxiracetam benefits, its neuroprotective qualities are often the most underappreciated.

What Are Warnings And Possible Side Effects Of Oxiracetam?

Like most Racetams, Oxiracetam is well tolerated and side effects are rare and usually mild. Some studies have been conducted on high dose Oxiracetam use over long periods, finding the drug is well tolerated by the vast majority of users [9]. What side effects do occur are typically mild and stop upon discontinuing the drug. Typical Oxiracetam side effects include headache, insomnia, and nervousness. The stimulant effects of oxiracetam may also induce restlessness in some individuals.

Many users find that headache issues with Oxiracetam can be solved by introducing a Choline source. Because Racetams cause an increase in acetylcholine production it may partially deplete the body's supply of choline, an important precursor to acetylcholine. For an average Oxiracetam dosage, taking 400mg - 650mg of Choline bitartrate can alleviate headaches associated with low choline levels.

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